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Former AstraZeneca U.S. medical director for Seroquel Wayne MacFadden confessed his multiple sexual affairs, and his offer of drugs to one of the women he was sleeping with, to lawyers in December ., SEROQUEL XR is a once-daily tablet approved in adults for (1) add-on treatment to antidepressants for patients with major depressive disorder (MDD) who did not have an adequate response to antidepressant therapy; (2) acute depressive episodes in bipolar disorder; (3) acute manic or mixed episodes in bipolar disorder alone or with lithium or divalproex; (4) long-term treatment of bipolar ., Seroquel is not a controlled substance, but there is still a risk of abuse or addiction. It is important to understand how this drug can affect people, especially if someone is taking it improperly. This information can help people to know when it is time to seek treatment., Melasma is a condition in which areas of the skin become darker than the surrounding skin. Doctors call this hyperpigmentation. It typically occurs on the face, particularly the forehead, cheeks and above the upper lip. The dark patches often appear on both sides of the face in a nearly identical pattern., I have taken every Drug Available and they all cause weight gain. I have been stable for 8 years. I take 800 mg to 1,400 mg of Seroquel daily. If I don�t take it at the same time, I get manic. I was a Size 4 my entire life. when I started talking Bipolar Meds I gained 75 lbs . I have managed to lose some weight by using a food diary.